Remix Therapeutics Enters Strategic Collaboration with Roche to Harness RNA Modulation for Novel Drug Discovery

Remix Therapeutics, a clinical-stage biotechnology company specializing in small molecule therapies targeting RNA processing, has unveiled a significant collaboration and license agreement with the global healthcare giant Roche. The announcement, made on January 3, 2024, outlines a partnership focused on the discovery and development of small molecule therapeutics utilizing the company's innovative REMaster drug discovery platform.

Under the terms of the agreement, Remix will receive an upfront payment of $30 million and is eligible for up to $12 million in near-term milestone payments. The collaboration also includes the potential for preclinical, clinical, commercial, and sales milestones, amounting to a substantial $1 billion, in addition to tiered royalties. In exchange, Roche secures exclusive rights to specific targets identified through the company's REMaster platform. The collaboration structure entails Remix conducting discovery and preclinical activities, while Roche takes the lead in development and commercialization of any resulting products.

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Peter Smith, Ph.D., President, and Chief Executive Officer of Remix Therapeutics, expressed enthusiasm about partnering with Roche, citing the alignment of their expertise and dedication to RNA-targeted interventions. He highlighted the opportunity to leverage company's cutting-edge REMaster drug discovery platform to advance the science of interfering with RNA targets and develop new medicines.

James Sabry, Global Head of Roche Pharma Partnering, echoed the sentiment, expressing admiration for Remix's scientific accomplishments with the REMaster platform. Sabry emphasized that the collaboration aligns well with the company's strategic vision to collaborate with partners pursuing innovative approaches to discovering and developing new medicines, particularly in areas of high unmet medical need.

Remix Therapeutics, as a clinical-stage biotechnology company, is dedicated to developing small molecule therapies designed to reprogram RNA processing and effectively address the underlying drivers of various diseases. The REMaster technology platform, a cornerstone of Remix's approach, facilitates the identification of RNA processing patterns, allowing for the modulation of gene expression.

Importantly, the company's unique therapeutic approach holds the potential to reshape the way genes are read from the genome, offering possibilities to correct, enhance, or eliminate gene messages and address disease drivers at their origin. The collaboration with Roche positions it at the forefront of RNA-focused drug discovery, providing an avenue to translate cutting-edge science into impactful medicines.

The strategic collaboration between Remix Therapeutics and Roche signifies a significant advancement in the field of RNA modulation for drug discovery. The partnership capitalizes on the company's REMaster platform and Roche's global reach and expertise, promising innovative solutions to address unmet medical needs and potentially revolutionize therapeutic approaches.