Medical Devices
Alameda, California

Overall Rank: 14
Category: Medical Devices
Category Rank: 4


  • Top HealthTech Company of 2022


Penumbra, Inc. is a global healthcare company which designs, develops, manufactures, and markets innovative therapies to address complicated medical conditions in a novel way, supporting healthcare providers, hospitals, and clinics in more than 100 countries. Penumbra has redefined care across conditions that impact millions of Americans, including ischemic stroke, peripheral blood clots (clots throughout the body, such as pulmonary embolisms), and aneurysms with first-to-market minimally invasive interventional medical devices that have improved clinical outcomes. Penumbra recently expanded into immersive healthcare using virtual reality to inspire and empower potentially millions of patients to engage and challenge themselves more fully in their physical and cognitive rehabilitation and mental wellness.

As a global market leader that continues to experience double-digit revenue growth year-over-year, Penumbra is committed to advancing innovations that address unmet needs and help as many people as it can with its technologies.


Key Products

The Penumbra System®

The Penumbra System® is a fully-integrated system designed specifically for mechanical thrombectomy, first receiving 510(k) clearance by the FDA in December 2007. It is intended for use in the revascularization of patients with acute ischemic stroke secondary to intracranial large vessel occlusions.


Penumbra has combined advanced engineering with features of current 10-System coils to create SMART COIL®, an embolization system designed to simplify complex cases.

BENCHMARK™ BMX™ 96, Neuron MAX® and BENCHMARK™ 071

Penumbra offers access devices specifically designed to facilitate the treatment of a wide range of conditions, including disorders in the most challenging neurovasculature. Penumbra introduced its first neuro access device in 2007 and has since expanded its intracranial access products such as BENCHMARK™ BMX™ 96, Neuron MAX® and BENCHMARK™ 071. These innovative devices are designed to address additional clinical challenges specific to the neurovascaulture.

Artemis™ Neuro Evacuation Device

Penumbra’s second generation device, Artemis™ Neuro Evacuation Device, is specifically designed for the controlled evacuation of fluids and tissues from the Ventricular System and Cerebrum. Artemis is a minimally invasive surgical tool that utilizes Pump MAX™ for powerful and controlled hematoma evacuation.